Our Papers and Reviews

In Vitro Mechanical Stimulation to Reproduce the Pathological Hallmarks of Human Cardiac Fibrosis on A Beating Chip and Predict The Efficacy of Drugs and Advanced Therapies

Roberta VisoneCamilla PaolettiAlessandro CordialeLetizia NicolettiCarla DivietoMarco RasponiValeria ChionoPaola Occhetta
Advanced Healthcare Materials, Nov 2023

 doi: 10.1007/s12551-021-00841-6

LivHeart: A Multi Organ-on-Chip Platform to Study Off-Target Cardiotoxicity of Drugs Upon Liver Metabolism

Erika FerrariRoberta VisoneElisa MontiEnrica TorrettaMatteo MorettiPaola OcchettaMarco Rasponi.
Advanced Materials Technologies, Jan 2023

 doi: 10.1007/s12551-021-00841-6

Predicting human cardiac QT alterations and pro-arrhythmic effects of compounds with a 3D beating heart-on-chip platform

Roberta Visone, Ferran Lozano-Juan, Simona Marzorati, Massimo Walter Rivolta, Enrico Pesenti, Alberto Redaelli, Roberto Sassi, Marco Rasponi and Paola Occhetta
Toxicological Sciences, Oct 2022


Current strategies of mechanical stimulation for maturation of cardiac microtissues

Maria Carlos-Oliveira M.,   Lozano-Juan F., Occhetta P.,  & Visone R.,  Rasponi M.
Biophysical Reviews, Sept 2021

 doi: 10.1007/s12551-021-00841-6

Micro-electrode channel guide (µECG) technology: an online method for continuous electrical recording in a human beating heart-on-chip.

Visone R., Ugolini G. S.,  Cruz-Moreira D., Marzorati S.,  Piazza S., Pesenti E., Redaelli A., Moretti M., Occhetta P. and Rasponi M.
Biofabrication , Feb 2021

doi: 10.1088/1758-5090/abe4c4

Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model.

Occhetta P, Mainardi A, Votta E, Vallmajo-Martin Q, Ehrbar M, Martin I, Barbero A, Rasponi M. 
Nat Biomedical Engineering, Jul 2019

 doi: 10.1038/s41551-019-0406-3. 

A microscale biomimetic platform for generation and electro-mechanical stimulation of 3D cardiac microtissues.

Visone R, Talò G, Occhetta P, Cruz-Moreira D, Lopa S, Pappalardo OA, Redaelli A, Moretti M, Rasponi M.
APL Bioengineering , Oct 2018

doi: 10.1063/1.5037968.

A three-dimensional in vitro dynamic micro-tissue model of cardiac scar formation.

Occhetta P, Isu G, Lemme M, Conficconi C, Oertle P, Räz C, Visone R, Cerino G, Plodinec M, Rasponi M, Marsano A.
Integr Biol (Camb), March 2018 

 doi: 10.1039/c7ib00199a

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues.

Marsano A, Conficconi C, Lemme M, Occhetta P, Gaudiello E, Votta E, Cerino G, Redaelli A, Rasponi M.
Lab on a Chip, Feb 2016

doi: 10.1039/C5LC01356A