uBeat® Technology

The uBeat® platform supports the culture of 3 biologically independent 3D microtissues within a single device. In each culture chamber microfluidic channels are separated by rows of hanging pillars. Geometry of these features dictates the mechanical stimulation received in the cell construct.
The uBoX actuator pressurizes the actuation layer underneath the cell culture layer to transfer a controlled mechanical stimulation to the cell constructs by means of the patented uBeat® technology. The uBeat® technology can be adopted to both maturate and differentiate human tissue in vitro and to develop mechanically-related pathologies on chip.

Geometry

Mechanical
Stimuli

Reliable

The stroke distance only depends on the pillars' gap.

Tunable

The pillars gap modulates the stimulation intensity.

Versatile

The type of stimulation is defined by the pillars' shape.

uBeat®Platform

Cell Culture Layer Top View

Cell Culture Layer – Top View

High Data Content

Miniaturized

3D microtissue: small volumes vs high cell density

Compatible

With standard biological assays and protocols Live/Dead assays Immunofluorescence PCR ELISA Dextran Permeability Proteomics Mass Spectrometry

The uBeat® technology can be adopted to both maturate and differentiate human tissue in vitro and to develop mechanically-related pathologies on chip.